Description
The MSUD Screening Assay is a colorimetric test for newborn screening of maple syrup urine disease by detecting specific amino acid metabolites in dried blood spots.
Maple Syrup Urine Disease (MSUD) Screening Assay
In the first reaction of the NEONATAL MSUD Screening Assay, an enzyme, the leucine dehydrogenase, converts BCAAs in the sample to α-ketoisocaproate acid and NADH. Thereafter, the presence of NADH is quantified by colorimetry using tetrazolium salt. The results are read by measuring absorbance for which staining intensity will be proportional to the concentration of BCAAs in the sample.
Format: 288 – 576 – 1920 determinations
Storage: At 2-8°C
Possible automation: Semi-automatisation
Turn around time: Less than 1.5 hour
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