Description
This enzyme test screens newborns for phenylketonuria using a colorimetric assay in dried blood spots, designed for professional diagnostic labs.
Phenylketonuria (PKU) (colo)
The enzymatic reaction of the NEONATAL PKU Screening Assay is performed in 2 stages. In the first reaction, an enzyme, phenylalanine dehydrogenase, converts phenylalanine contained in the newborn sample to phenylpyruvate and NADH. Subsequently, the presence of NADH is quantified by colorimetry using tetrazolium salt. The measured absorbance intensity is then proportional to the phenylalanine concentration in the sample.
Format: 288 – 576 – 1920 determinations
Storage: At 2-8°C
Possible automation: Semi-automatisation
Turn around time: Less than 1.5 hour
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