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Galactosemia TGAL

The enzymatic reaction of the NEONATAL Total-Galactose Screening Assay is carried out in two stages. In the first stage, two enzymes—alkaline phosphatase and galactose dehydrogenase—convert total galactose (Galactose-1-phosphate and free galactose) in the newborn sample into products, such as NADH. In the second stage, the presence of NADH is quantified using colorimetry with tetrazolium salt. The absorbance intensity measured is directly proportional to the total galactose concentration in the sample.

General information

Format: 288 – 576 – 1920 determinations
Storage: At 2-8°C
Possible automation: Semi-automatisation
Turn around time: Less than 1.5 hour

SKU: GAL-006 Categories: ,
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Description

Intended for use in diagnostic laboratories (not for self‑testing), this assay is performed on dried blood spot samples (903® or 226). The enzymatic reaction proceeds in two steps: first, enzymes (alkaline phosphatase and galactose dehydrogenase) convert total galactose to products that generate NADH; second, NADH is used in a colorimetric reaction (e.g. with tetrazolium salt) giving a measurable absorbance proportional to galactose concentration.

Galactosemia is usually due to deficiency in the GALT enzyme, leading to toxic accumulation of galactose and its metabolites. If untreated, it can result in liver damage, cataracts, failure to thrive, sepsis, and intellectual disability. Dietary restriction of galactose is the mainstay of treatment.

The kit supports multiple packaging options, is compatible with manual and automated operations, and is manufactured under European ISO / CE standards.

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